Thermo-Responsive Electrospun Nanofibers from Poly( N-isopropylacrylamide )/Polyvinyl Pyrrolidone Blends

作     者：吕瑶 吴焕岭 李赫宇 潘琪霞 朱利民 

作者机构：College of ChemistryChemical Engineering and BiotechnologyDonghua University Jiuzhou College of PharmacyYancheng Institute of Industry Technology 

出 版 物：《Journal of Donghua University(English Edition)》 (东华大学学报（英文版）)

年 卷 期：2017年第34卷第1期

页      面：152-158页

学科分类：100702[医学-药剂学] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：Science and Technology Commission of Shanghai Municipality,China(No.16410723700) "111 Project"Biomedical Textile Materials Science and Technology,China(No.B07024) UK-China Joint Laboratory for Therapeutic Textiles Based at Donghua University 

主　　题：poly(N-isopropylacrylamide)(PNIPAAm) polyvinyl pyrrolidone(PVP) electrospinning drug release 

摘      要：A novel nanofiber composite poly(N-isopropylacrylamide)(PNIPAAm)/polyvinyl pyrrolidone(PVP)was successfully prepared by *** medicated fibers loaded with ketoprofen(KET)as a model drug were prepared.X-ray diffraction(XRD)demonstrated that the drug was presented in the fibers with an amorphous *** scanning and transmission electron microscopy showed that the fibers had an even diameter and smooth surface,and no phase separation was *** KET loaded nanofibers did not affect the morphology of the fibers,and no drug aggregation was separated from the polymer *** contact angle measurements proved that the PNIPAAm/PVP fibers switched from hydrophilic to hydrophobic when the temperature increased the lower critical solution temperature of 32℃.In vitro drug release studies were also undertaken and the result indicated that the PNIPAAm/PVP blend nanofiber presented the properties of the two polymers,having temperature-sensitive systems with sustained release *** addition,MTT assay demonstrated that the nanofiber film was non-toxic and suitable for cell ***,the nanofiber can be used as thermoresponsive carriers for sustained release of poor water soluble drugs.