Development and characterization of α-tricalcium phosphate/monocalcium aluminate composite bone cement
Development and characterization of α-tricalcium phosphate/monocalcium aluminate composite bone cement作者机构：Ceramic Department Instituto de Cerámica y Vidrio-CSIC Madrid Spain Engineering School Materials Department Universidade Federal do Rio Grande do Sul Porto Alegre RS Brazil General Chemistry Department Chemistry Faculty Havana University Cuba
出 版 物：《Journal of Biomedical Science and Engineering》 (生物医学工程（英文）)
年 卷 期：2012年第5卷第8期
页 面：448-456页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Calcium Phosphate Cements Calcium Aluminate Cements Hydroxyapatite In Vitro
摘 要：Calcium phosphate cements have received much attention in recent decades owing to their biocompatibility, in situ handling, and shaping abilities. However, their low initial mechanical strength is still a major limitation. On the other hand, calcium aluminate cements (CACs) set fast and have a high initial strength and good corrosion resistance in contact with body fluids, making them excellent dental restorative materials. Therefore, the chemical, mechanical and biological properties of new-TCP/CA cement after aging in simulated body fluid (SBF) were investigated. The results indicated that the composites have setting times not appropriated for immediate applications and have degradation rates higher than those of the traditional CPCs. Moreover, the compressive strength of composite was lower than 5MPa and did not increase with SBF immersion. However, the α-TCP/CA composites showed a higher bioactivity at early stages and were not only more biocompatible but also more noncytotoxic.
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