Seroepidemiology of Helicobacter pylori infection in general population in a northern Mexican city

作     者：Cosme Alvarado-Esquivel Agar Ramos-Nevarez Sandra Margarita Cerrillo-Soto Lucio Martinez-Ramirez Carlos Alberto Guido-Arreola Fernando Arturo Munoz-Gonzalez 

作者机构：Biomedical Research LaboratoryFaculty of Medicine and NutritionJuarez University of Durango StateDurangoMexico Clinica de Medicina FamiliarInstituto de Seguridad y Servicios Sociales de los Trabajadores del Estado(ISSSTE)DurangoMexico 

出 版 物：《Health》 (健康（英文）)

年 卷 期：2014年第6卷第1期

页      面：27-32页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Helicobacter pylori Seroprevalence General Population Epidemiology Mexico 

摘      要：Background: The seroepidemiology of Helicobacter pylori infection in general population in Durango City, Mexico has not been previously studied. Aims: To determine the seroprevalence of anti-H. pylori antibodies in the general population in Durango City, Mexico;and to determine socio-demographic, clinical, and behavioral characteristics of the general population associated with H. pylori seropositivity. Methods: The prevalence of anti-H. pylori IgG antibodies was examined in 345 individuals in Durango City, Mexico, using enzyme-linked immunoassays. Socio-demographic, clinical, and behavioral characteristics of the general population associated with H. pylori seroprevalence were also investigated. Results: In total, 231 (67%) of the 345 participants (mean age, 45.3. ± 17.5 years) had H. pylori IgG antibodies, 146 (63.2%) of whom had H. pylori IgG antibody levels higher than 100 U/mL. Both H. pylori seroprevalence and antibody levels increased significantly with age, and were similar in males and females. An increased H. pylori seroprevalence was found in subjects with low education and employed. In contrast, a low seroprevalence was found in subjects living in suburban areas. One of four subjects with gastritis symptoms had anti-H. pylori antibodies. The seroprevalence of H. pylori was significantly higher among women with abortion history than among those without such history. Multivariate analysis of behavioral variables showed that H. pylori seropositivity was negatively associated with raising farm animals (OR = 0.48;95% CI: 0.25-0.91;P = 0.02). Conclusions: In the general population studied, H. pylori seroreactivity increased significantly with age, not only in frequency but also in intensity. Residence, education, and occupation of the study population influenced the seropositivity rate of H. pylori.