Degradation of naturally occurring and engineered antimicrobial peptides by proteases
Degradation of naturally occurring and engineered antimicrobial peptides by proteases作者机构：Department of Obstetrics Gynecology and Reproductive Sciences University of Pittsburgh Pittsburgh USA.
出 版 物：《Advances in Bioscience and Biotechnology》 (生命科学与技术进展（英文）)
年 卷 期：2011年第2卷第6期
页 面：404-408页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Microbicides HIV Anti-HIV Antimicrobial Peptides Proteases
摘 要：We hypothesized that current antimicrobial peptides should be susceptible to proteolytic digestion. The antimicrobial peptides: Griffithinsin, RC-101, LL-37, LSA-5, PSC-RANTES and DJ007 were degraded by commercially available proteases. Two different species of anaerobic vaginal flora, Prevotella bivia and Porphyromonas asaccharolytica also degraded the materials. Griffithsin was resistant to digestion by 8 of the 9 proteases and the bacteria while LL-37 was the most sensitive to protease digestion. These data suggests most of the molecules may not survive for very long in the proteolytic rich environments in which they are intended to function.
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