The Prevalence of Parasitic Human Intestinal Helminthes and the Efficacy of Anthelmintic Drug in Children in Uzo-Uwani Local Government Area, Enugu State, Nigeria
The Prevalence of Parasitic Human Intestinal Helminthes and the Efficacy of Anthelmintic Drug in Children in Uzo-Uwani Local Government Area, Enugu State, Nigeria作者机构：Department of Pharmacognosy Faculty of Pharmacy University of Ibadan Ibadan Nigeria Department of Basic and Applied Sciences Federal Polytechnic Bali Nigeria Department of Basic and Applied Sciences Federal Polytechnic Bali Nigeria Department of Veterinary Public Health Faculty of Veterinary Medicine Ahmadu Bello University Zaria Nigeria
出 版 物：《Open Journal of Medical Microbiology》 (医学微生物学（英文）)
年 卷 期：2013年第3卷第4期
页 面：213-218页
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
主 题：Prevalence Anthelmintic Levamisole Children Ascaris lumbricoides Trichuris trichiura
摘 要：Introduction: A study on the current status of parasitic intestinal helminthes and the efficacy of anthelmintic drug was carried out among primary school pupils at Community Primary School Ogurugu, Uzo-Uwani Local Government Area, Enugu State. Objectives: The research was conducted in order to determine the prevalence of human intestinal helminthes among primary school pupils, and also to determine the prevalence in relation to age and sex, and to check the efficacy of anthelmintic drug (Levamisole) on the worms, in Ogurugu Uzo-Uwani Local Government Area, Enugu State, Nigeria. Methods: A total of 242 faecal samples were collected randomly from the school children and analyzed using standard parasitological procedures. Results: Data obtained showed an overall prevalence of 143 (59.1%) out of 242 samples and that the efficacy of anthelmintic drug Ergamisole? (Levamisole R12564;Unicure *** India) 50 mg in reducing the worm burden was 99 (82.5%) in 120 samples treated. Age related prevalence and efficacy of anthelmintic varied across the sample groups. There was no significant difference in sex related infections in the sample group (P 0.5). The efficacy of the drug reduces with the increase in age. Also the efficacy of Levamisole drug in reducing the worm burden were hookworm 59 (89.5%), Ascaris 24 (85.7%), Trichuris 26 (78.6%) while Taenia and Strongyloides showed drug resistance. This indicates that a single dose of the medication is not enough for total elimination of these endo parasites. Conclusion: The study revealed that poor hygienic practices as well as unsanitary conditions were responsible for high prevalence recorded in the area, and advocated health education through primary health care and mass deworming of primary school children as control measures.
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