The Prevalence and Outcomes of Influenza Virus Infection in Heart Failure Patients in Brazil: Influenza Infection in Heart Failure

作     者：Henrique Godoy Juliana Soares Paula Zanellatto Neves N.C.J. Bellei Dirceu R. Almeida 

作者机构：Division of Cardiology Department of Medicine Federal University of Sao Paulo Sao Paulo Brazil Hospital Epidemiology Committee Federal University of Sao Paulo Sao Paulo Brazil Clinical Virology Laboratory Division of Infectious Diseases Department of Medicine Federal University of Sao Paulo Sao Paulo Brazil 

出 版 物：《Advances in Infectious Diseases》 (传染病进展（英文）)

年 卷 期：2015年第5卷第3期

页      面：95-100页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Influenza Virus Heart Failure Epidemiology 

摘      要：Background: Respiratory tract infections were associated with acute exacerbations of heart failure (HF). However, the role of the influenza virus, a major agent of such infections, in this population remained unclear. Method: During the influenza virus seasons of 2013 and 2014 we prospectively assessed influenza respiratory illnesses in a cohort of adults primarily hospitalized for management of acute decompensated HF and a cohort of HF outpatients. Qualitative RT-PCR for?influenza?A (A/H1, A/H12009pdm, A/H3) and B virus testing was performed on nasopharyngeal swab samples. Result: A total of 121 patients were included, 58.3% males (n?= 70), mean age 57.7 years old (±14.0), mean left ejection fraction 35.3 (±9.8). Of these, 50.4% were inpatients (n?= 61). The prevalence of symptoms of respiratory infections was 28.0% (n?= 34) and 4.9% (n?= 6) of all samples were positive for influenza virus. Only influenza A was detected and all cases were among inpatients. Influenza-positive patients had a greater need for antimicrobials (83.3%,?n?= 5;16.3%,?n= 9;?p?= 0.001) and for mechanical ventilation (50.0%,?n?= 3;3.6%,?n?= 2;?p? 0.001) than Influenza-negative patients. The prevalence of influenza virus was not related to mortality (OR 4.58;?p?= 0.16). Conclusion:?Although not common, the influenza virus infection resulted in worst outcomes, with a greater need for antimicrobials and mechanical ventilation. Immunization and antiviral treatment in high risk patients may positively impact their outcomes.