HPLC Polyphenolics Profile and H<sub>2</sub>O<sub>2</sub> Induced Cytoprotective Effect of Salacia oblonga Extracts on Human Lymphocytes
HPLC Polyphenolics Profile and H<sub>2</sub>O<sub>2</sub> Induced Cytoprotective Effect of Salacia oblonga Extracts on Human Lymphocytes作者机构：Centre for Biotechnology Institute of Science and Technology Jawaharlal Nehru Technological University Hyderabad India
出 版 物：《Advances in Biological Chemistry》 (生物化学进展（英文）)
年 卷 期：2016年第6卷第1期
页 面：19-27页
学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学]
主 题：Salacia oblonga Poly Phenol Cytoprotective Lymphocytes H2O2
摘 要：Salacia oblonga (Wall.) belonging to the family Celastraceae is an important medicinal plant available in India and Sri Lanka. It possesses an array of pharmacological and therapeutic properties. In the present study phenolic compounds of S. oblonga methanolic extracts were estimated by high performance liquid chromatography (HPLC) indicating the presence of catechin, quercetin, synapic acid and syringic acid. The study involved evaluation of S. oblonga extracts for cytotoxic and cytoprotective effects on human lymphocytes. Aerial extracts have significant protective activity against hydrogen peroxide (H2O2) induced cytotoxic activity in comparison to the root extracts. The results relate the cytoprotective effect of S. oblonga due to the presence of poly phenols and other phytochemicals, as they have significant ability to remove free radicals or reactive species and might induce the expression of antioxidant enzymes inside the cells.
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