α-Glucosidase Inhibition by New Schiff Base Complexes of Zn(II)
α-Glucosidase Inhibition by New Schiff Base Complexes of Zn(II)作者机构：Department of Analytical and Bioinorganic Chemistry Kyoto Pharmaceutical University Kyoto Japan Department of Health Sports and Nutrition Faculty of Health and Welfare Kobe Women’s University Hyogo Japan
出 版 物：《Open Journal of Inorganic Chemistry》 (无机化学期刊（英文）)
年 卷 期：2016年第6卷第2期
页 面：114-124页
学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学]
主 题：α-Glucosidase Inhibitory Effect Zn(II) Complexes Schiff Bases Diabetes Mellitus
摘 要：There are many reports that divalent alkaline earth, first-row transition metals, and Zn(II) ions have α-glucosidase inhibitory effects. Cu(II) and Zn(II) ions, in particular, have strong α-glucosidase inhibitory effects. Several Schiff bases also display α-glucosidase inhibitory effects. In this study, we focused on safe and highly effective complexes including Zn(II) ion. We prepared and characterized the Zn(II) complexes with four different Schiff bases (N-salicylidene-β-alanine (N-sβ), N-N’-bis (salicylidene) ethylenediamine (N-bsE), N, N’-bis (salicylidene)-phenylenediamine (N-bsP), and 1-[(2-dimethylaminoethylimino) methyl]naphtholate (DMN)) and investigated their α-glucosidase inhibitory effects in vitro, using α-glycosidases from Saccharomyces sp. and rat small intestine, and in vivo, using a sucrose tolerance test. The Zn(II) complexes with DMN showed the highest in vitro and in vivo α-glucosidase inhibitory effects in this study.
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