A Case of Fungal Keratitis Secondary to Cylindrocarpon Destructans

作     者：Rajen Tailor Ibrahim Elaraoud Mike Quinlan 

作者机构：Birmingham and Midlands Eye Centre City Hospital Birmingham England Russells Hall Hospital Dudley England. University Hospitals of Coventry and Warwick Coventry England 

出 版 物：《Open Journal of Ophthalmology》 (眼科学期刊（英文）)

年 卷 期：2012年第2卷第2期

页      面：31-33页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Cylindrocarpon Destructans Ciclosporin Fungal Keratitis Penetrating Keratoplasty Topical Steroids 

摘      要：Purpose: To report the first human case of fungal keratitis caused by Cylindrocarpon destructans and to highlight the issues with the use of topical steroids, the duration of antifungal treatment and the potential role of topical ciclosporin. Methods: A patient presented following being injured in the left eye by a fuchsia plant. Data was collected by slit lamp examination and review of the case notes and microbiology reports. Results: No organisms were cultured from a corneal scrape however cultures from a corneal biopsy identified cylindrocarpon species morphologically resembling Cylindrocarpon destructans. The patient responded well to topical amphotericin and clotrimazole and oral voriconazole but, developed a corneal perforation, which required an urgent tectonic penetrating keratoplasty (PKP). Despite being on topical dexamethasone and natamycin, the patient presented two months post-operatively with a corneal epithelial defect and a large hypopyon. Subsequently, the patient developed a deep corneal infiltrate and corneal vascularisation with a persistent epithelial defect. Conclusion: This is the first reported case of keratitis caused by Cylindrocarpon destructans. The case highlights: the contentious issues in the use of topical steroids following PKP and the duration of antifungal treatment both in primary infection and following PKP. Furthermore, the case accentuates a potential role for ciclosporin as an alternative to steroids following PKP.