Autism-related protein MeCP2 regulates FGF13 expression and emotional behaviors

作     者：BO Yuan Tian-lin Cheng Kan Yang Xu Zhang Zilong Qiu 

作者机构：Institute of Neuroscience Key Laboratory of Primate Neurobiology CAS Center for Excellence in Brain Science and Intelligence Technology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China Institute of Chemistry and Bioengineering Donghua University Shanghai 200051 China Shanghai Clinical Research Center Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China 

出 版 物：《Journal of Genetics and Genomics》 (遗传学报（英文版）)

年 卷 期：2017年第44卷第1期

页      面：63-66页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 100205[医学-精神病与精神卫生学] 10[医学] 

基　　金：supported by the Strategic Priority Research Program of Chinese Academy of Sciences(Grant No.XDB02050400) the National Natural Science Foundation of China(Grant No. #91432111) to Z.Qiu 

主　　题：FGF Autism-related protein MeCP2 regulates FGF13 expression and emotional behaviors microRNAs 

摘      要：Methyl-CpG binding protein 2 （MeCP2） has a crucial role in transcriptional regulation and neural development （Ausi6 et al., 2014）. Loss of function mutations of MECP2 in human lead to Rett syndrome （RTT）, a severe neurodevelopmental disorders （Amir et al., 1999）, whereas individuals with the chromosomal duplications containing the MECP2 locus showed severe autism-like symptoms （Ramocki et al., 2009）.