Clinicopathological and prognostic significance of aberrant Arpin expression in gastric cancer

作     者：Tao Li Hong-Mei Zheng Nai-Mei Deng Ying-Jian Jiang Jiang Wang Dian-Liang Zhang 

作者机构：Center of Colon and RectumQingdao Municipal HospitalQingdao University Infection DepartmentQingdao Municipal Hospital 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2017年第23卷第8期

页      面：1450-1457页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Clinicopathological 特征 胃的癌症 Arpin Arp2/3 建筑群 预后 

摘      要：AIM To detect the expression of Arpin, and determine its correlation with clinicopathological characteristics and the prognosis of gastric cancer(GC) *** A total of 176 GC patients were enrolled as study subjects and classified into groups according to different clinicopathological variables. GC mucosal tissues were obtained via surgery. Another 43 paraffin-embedded tissue blocks of normal gastric epithelium( 5 cm away from the edge of the tumor) were included in the control group. Immunohistochemistry(IHC) for the Arpin and Arp3 proteins was performed on the formalinfixed, paraffin-embedded GC tissues. Additionally, expression of the Arpin protein in 43 normal gastric tissues was also determined using *** Expression of the Arpin protein in GC was lower than that in normal gastric mucosa(30.68% vs 60.47%, P 0.001). A χ2 test of the 176 GC samples used for IHC showed that decreased Arpin expression was associated with advanced TNM stage(P 0.01) and the presence or absence of lymph node metastasis(80.92% vs 35.56%, P 0.001). Additionally, a significant correlation was observed between the expression of Arpin and the presence of the Arp2/3 complex in GC tissues(χ2 = 30.535, P 0.001). Moreover, a multivariate Coxregression analysis revealed that Arpin expression [hazard ratio(HR) = 0.551, P = 0.029] and TNM stage(HR = 5.344, P = 0.001) were independent prognostic markers for overall survival of GC patients. Regarding the 3-year disease-free survival(DFS), the recurrence rate of GC patients with low Arpin expression levels(median DFS 19 mo) was higher than that in the highArpin-expression group(median DFS 34 mo, P = 0.022).CONCLUSION Low Arpin levels are associated with clinicopathological variables and a poor prognosis in GC patients. Arpin may be regarded as a potential prognostic indicator in GC.