Photodynamic Therapy Activities of 10-(4-Formylphenyl)-5,15-bis(pentafluorophenyl)corrole and Its Gallium Complex
Photodynamic Therapy Activities of 10-(4-Formylphenyl)-5,15-bis(pentafluorophenyl)corrole and Its Gallium Complex作者机构:Department of Chemistry Key Laboratory of Functional Molecular Engineering of Guangdong Provinee South China University of Technology Guangzhou Guangdong 510641 China School of Pharmacy Guangdong Pharmaceutical University Guangzhou Guangdong 510006 China State Key Laboratory of Optoelectronics Materials and Technologies Sun-Yat Sen University Guangzhou Guangdong 510275 China
出 版 物:《Chinese Journal of Chemistry》 (中国化学(英文版))
年 卷 期:2017年第35卷第1期
页 面:86-92页
核心收录:
学科分类:1007[医学-药学(可授医学、理学学位)] 1002[医学-临床医学] 100214[医学-肿瘤学] 0703[理学-化学] 10[医学]
基 金:This work was supported by National Natural Sci-ence Foundation of China (NNSFC) under Grant (Nos. 21371059 21671068) the National Science Foundation of Guangdong Province (No. 2016A030313728) the Open Fund of State Key Laboratory of Optoelectronic Materials and Technologies (Sun Yat-sen University) (No. OEMT-2015-KF-05).
主 题:corrole gallium photodynamic therapy tumor cell
摘 要:10-(4-Formylphenyl)-5,15-bis(pentafluorophenyl)corrole 1 and its gallium complex 1-Ga were used to investigate their photocytotoxicity in liver cancer (BEL-7402), lung cancer (A549) and cervical cancer (Siha, Hela) cell lines. Among all the tested tumor cells, Siha tumor cells were the most sensitive to photodynamic therapy (PDT) treatment by 1 and 1-Ga. PDT IC50 of 1 and 1-Ga toward Siha tumor cell reaches 1.3 and 0.8 gmol/L respectively, which is 10-fold higher than that of cisplatin. 1 and 1-Ga might pass across the tumor cell membrane smoothly without the help of carrier protein, and mainly localized in the cytoplasm of tumor cell. After PDT treatment, the intracellular reactive oxygen species (ROS) level increased and the mitochondrial membrane potential decreased significantly, which would finally result in the apoptosis of tumor cells.