Transcriptome Analysis of Monozygotic Twin Brothers with Childhood Primary Myelofibrosis

作     者：Nan Ding Zhaojun Zhang Wenyu Yang Lan Ren Yingchi Zhang Jingliao Zhang Zhanqi Li Peihong Zhang Xiaofan Zhu Xiaojuan Chen Xiangdong Fang 

作者机构：CAS Key Laboratory of Genome Sciences and InformationBeijing Institute of GenomicsChinese Academy of SciencesBeijing 100101China College of Life SciencesUniversity of Chinese Academy of SciencesBeijing 100049China Sino-Danish CollegeUniversity of Chinese Academy of SciencesBeijing 100190China State Key Laboratory of Experimental HematologyInstitute of Hematology and Blood Diseases HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300020China 

出 版 物：《Genomics, Proteomics & Bioinformatics》 (基因组蛋白质组与生物信息学报（英文版）)

年 卷 期：2017年第15卷第1期

页      面：37-48页

核心收录：

学科分类：1002[医学-临床医学] 100202[医学-儿科学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(Grant Nos.31471115,31401160,81300393,and 81300394) the Strategic Priority Research Program of the Chinese Academy of Sciences,Stem Cell and Regenerative Medicine Research,China(Grant No.XDA01040405) the National‘‘Twelfth Five-Year”Plan for Science&Technology Support,China(Grant No.2013BAI01B09) the National Key Scientific Instrument and Equipment Development Projects of China(Grant No.2011YQ03013404) the National High-tech R&D Program of China(Grant Nos.2015AA020101 and 2015AA020108) the State Key Laboratory of Experimental Hematology Pilot Project(Grant No.ZK13-05) the Nature Science Fund of Tianjin Municipal Science and Technology Commission,China(Grant No.12ZCDZSY18100) 

主　　题：Primary myeiofibrosis RNA-seq Apoptosis Monozygotic twin 

摘      要：Primary myelofibrosis （PMF） is a chronic myeloproliferative disorder in human bone marrow. Over 50% of patients with myelofibrosis have mutations in JAK2, MPL, or CALR. However, these mutations are rarely detected in children, suggesting a difference in the pathogenesis of childhood PMF. In this study, we investigated the response to drug treatment of a monozygotic twin pair with typical childhood PMF. The twin exhibited different clinical outcomes despite following