Preparation of Molecularly Imprinted Electrochemical Sensor for Detection of Vincristine Based on Reduced Graphene Oxide/Gold Nanoparticle Composite Film
Preparation of Molecularly Imprinted Electrochemical Sensor for Detection of Vincristine Based on Reduced Graphene Oxide/Gold Nanoparticle Composite Film作者机构：College of Chemistry and Material Science Shanxi Normal University Linfen Shanxi 041004 China
出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)
年 卷 期：2016年第34卷第12期
页 面：1268-1276页
核心收录：
学科分类：081704[工学-应用化学] 07[理学] 070304[理学-物理化学(含∶化学物理)] 080202[工学-机械电子工程] 08[工学] 0817[工学-化学工程与技术] 0703[理学-化学] 0802[工学-机械工程]
基 金：support of the Science Foundation of Shanxi Province
主 题：molecularly imprinted polymers electrochemical sensor reduced graphene oxide and gold nanocom-posites vincristine
摘 要：An innovative molecularly imprinted electrochemical sensor was fabricated based on reduced graphene oxide （RGO） and gold nanocomposite （Au） for rapid detection of vincristine （VCR）. The RGO-Au composite membrane was obtained via direct one-step electrodeposition technique of graphene oxide （GO） and chloroauric acid （HAuCl4） on the surface of a glassy carbon electrode （GCE） by means of cyclic voltammetry （CV） in the potential range be- tween -1.5 and 0.6 V in phosphate buffer solution （PBS） of pH 9.18, which is capable of effectively utilizing its superior electrical conductivity, larger specific surface area due to its synergistic effect between RGO and Au. The molecularly imprinted polymers （MIPs） were synthesized on the RGO-Au modified glassy carbon electrode surface with VCR as the template molecular, methyl acrylic acid （MAA） as the functional monomer, and ethylene glycol maleic rosinate acrylate （EGMRA） as a cross-linker. The performance of the sensor was investigated by cyclic voltammetry （CV）, differential pulse voltammetry （DPV） and electrochemical impedance spectroscopy （EIS） in de- tail. Under the optimum conditions, the fabricated sensor exhibited a linear relationship between oxidation peak current and VCR concentration over the range of 5.0×10 8 5.0×10^-6 mol.L l with a correlation coefficient of 0.9952 and a detection limit （S/N=3） of 2.6×10 8 mol.L^-1. The results indicated that the imprinted polymer films exhibited an excellent selectivity for VCR. The imprinted sensor was successfully used to determine VCR in real samples with recoveries of 90%-- 120% by using the standard addition method.
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