Modulating autophagy:a strategy for cancer therapy

作     者：Jun-Lin Li1,Shao-Liang Han2 and Xia Fan3 1Department of General Surgery,The Central Hospital of Yongzhou City,Yongzhou,Hunan 425000,P.R.China 2Department of General Surgery,First Affiliated Hospital of Wenzhou Medical College,Wenzhou,Zhejiang 325000,P.R.China 3State Key Laboratory of Trauma,Burns,and Combined Injury Research Institute of Surgery,Daping Hospital,Third Military Medical University,Chongqing 400042,P.R.China. 

作者机构：Department of General Surgery The Central Hospital of Yongzhou City Yongzhou Hunan People's Republic of China. leejunlin@*** 

出 版 物：《Chinese Journal of Cancer》 (CHINESE JOURNAL OF CANCER)

年 卷 期：2011年第30卷第10期

页      面：655-668页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：自噬作用 癌症治疗 调制 肿瘤抑制 抑癌基因 细胞器 人类疾病 能量代谢 

摘      要：Autophagy is a process in which long-lived proteins,damaged cell organelles,and other cellular particles are sequestered and *** process is important for maintaining the cellular microenvironment when the cell is under *** studies have shown that autophagy plays a complex role in human diseases,especially in cancer,where it is known to have paradoxical ***,autophagy provides the energy for metabolism and tumor growth and leads to cell death that promotes tumor *** link between autophagy and cancer is also evident in that some of the genes that regulate carcinogenesis,oncogenes and tumor suppressor genes,participate in or impact the autophagy ***,modulating autophagy will be a valuable topic for cancer *** studies have shown that autophagy can inhibit the tumor growth when autophagy modulators are combined with radiotherapy and/or *** findings suggest that autophagy may be a potent target for cancer therapy.