Anti-angiogenic effect of Artocarpus heterophyllus seed methanolic extract in ex ovo chicken chorioallantoic membrane

作     者：Swastika Oktavia Nastiti Wijayanti Bambang Retnoaji 

作者机构：Post Graduate ProgramBiology FacultyUniversitas Gadjah MadaYogyakartaIndonesia Department of BiologyScience and Pharmacy FacultyMathla'ul Anwar UniversityBantenIndonesia Laboratory of Animal PhysiologyFaculty of BiologyUniversitas Gadjah MadaYogyakartaIndonesia Laboratory of Animal Structure and DevelopmentFaculty of BiologyUniversitas Gadjah MadaYogyakartaIndonesia 

出 版 物：《Asian Pacific Journal of Tropical Biomedicine》 (亚太热带生物医学杂志（英文版）)

年 卷 期：2017年第7卷第3期

页      面：240-244页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：Supported by Beasiswa Unggulan Directorate General of Higher Education 2012 and BOPTN-WUR Universitas Gadjah Mada(Grant No.578A/KJM/XI/2015) 

主　　题：Angiogenesis Artocarpus heterophyllus CAM Ex ovo culture 

摘      要：Objective: To examine the anti-angiogenic potential of Artocarpus heterophyllus(A. heterophyllus) seed extract in chicken chorioallantoic membrane(CAM).Methods: This study used chicken CAM ex ovo culture to examine the potential antiangiogenic activity of A. heterophyllus seed methanolic extract. Basic fibroblast growth factor was used to induce the ectopic formation of blood vessels on CAM treated with extract. Blood vessel number was assessed by macroscopic and microscopic observation,and compared and analyzed for all treatments and ***: Macroscopic observation revealed that a dose of 35 mg/m L of methanolic extract of A. heterophyllus seeds could inhibit basic fibroblast growth factor-induced angiogenesis by 61% in chicken CAM ex ovo culture. This concurred with microscopic observations on the histological structure of blood vessels, which indicated that extract treatment repressed the formation of new blood ***: This is the first study to report the anti-angiogenic effect of methanolic extract derived from A. heterophyllus seeds and its potential as a candidate for future anticancer therapy.