Biological activity and toxicity of the Chinese herb Magnolia officinalis Rehder & E. Wilson(Houpo) and its constituents

作     者：Melanie POIVRE Pierre DUEZ 

作者机构：(Unit of Therapeutic Chemistry and Pharmacognosy Faculty of Medicine and Pharmacy Research Institute for Health Sciences and Technology University of Mons-UMONS Mons Belgium 

出 版 物：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 (浙江大学学报（英文版）B辑（生物医学与生物技术）)

年 卷 期：2017年第18卷第3期

页      面：194-214页

核心收录：

学科分类：0710[理学-生物学] 1007[医学-药学(可授医学、理学学位)] 0401[教育学-教育学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 04[教育学] 1001[医学-基础医学(可授医学、理学学位)] 0905[农学-畜牧学] 0906[农学-兽医学] 

主　　题：Magnolia bark Houpo Chinese herb Traditional Chinese medicine 

摘      要：Traditional Chinese herbal drugs have been used for thousands of years in Chinese pharmacopoeia. The bark of Magnolia officinalis Rehder ＆ E. Wilson, known under the pinyin name ＂Houpo＂, has been traditionally used in Chinese and Japanese medicines for the treatment of anxiety, asthma, depression, gastrointestinal disorders, headache, and more. Moreover, Magnolia bark extract is a major constituent of currently marketed dietary supplements and cosmetic products. Much pharmacological activity has been reported for this herb and its major compounds notably antioxidant, anti-inflammatory, antibiotic and antispasmodic effects. However, the mechanisms underlying this have not been elucidated and only a very few clinical trials have been published. In vitro and in vivo toxicity studies have also been published and indicate some intriguing features. The present review aims to summarize the literature on M. officinalis bark composition, utilisation, pharmacology, and safety.