1,3-Dipolar cycloaddition reaction for diastereoselective synthesis of functionalized dihydrospiro[indoline-3,2'-pyrroles]

作     者：Ping Wu Hong Gao Jing Sun Chao-Guo Yan 

作者机构：Department of Biochemical Engineering Yangzhou Polytechnic University College of Chemistry & Chemical Engineering Yangzhou University 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2017年第28卷第2期

页      面：329-332页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：financially supported by the National Natural Science Foundation of China (Nos. 21172189, 21572196) the Priority Academic Program Development of Jiangsu Higher Education Institutions 

主　　题：One-pot reaction 1 3-Dipolar cycioaddition Azomethine ylide Electron-deficient alkyne Spiro[indoline-3 2'-pyrrole] 

摘      要：The BF_3OEt_2 catalyzed one-pot 1,3-dipolar cycloaddition reaction of benzylamines,isatins and dimethyl acetylenedicarboxylate in dry methylene dichloride afforded the functionalized dihydrospiro[indoline-3,2＇-pyrroles]in moderate to good yields and with high *** reaction was accomplished by the tandem 1,3-dioplar cycloaddition of in situ generated azomethine ylide with acetylenedicarboxylate and the nucleophilic addition of pyrrole ring to second molecular acetylenedicarboxylate.