Syntheses and Anti-cancer Activities of Glycosylated Derivatives of Diosgenin
Syntheses and Anti-cancer Activities of Glycosylated Derivatives of Diosgenin作者机构：Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences Guiyang 550002 P R. China Key Laboratory of Chemistry for Natural Products of Guizhou Medical University Guiyang 550001 P. R. China
出 版 物：《Chemical Research in Chinese Universities》 (高等学校化学研究（英文版）)
年 卷 期：2017年第33卷第1期
页 面：80-86页
核心收录：
学科分类：07[理学]
基 金：Supported by the National Natural Science Foundation of China(Nos.81360479 81472609) and the Project of the Science and Technology Department of Guizhou Province China(Nos.QKHRC4037 QKHRCTD4026 QKHJZ2099)
主 题：Diosgenin Glycosylation Anti-cancer activity
摘 要：In order to obtain better anti-cancer compounds, nine glycosylated derivatives were designed and synthe- sized using diosgenin as starting material. Their structures were confn-med by 1H NMR, 13C NMR and MS spectra. The anti-cancer activities of intermediate compounds 5a-5i and the target compounds 6a-6i were investigated against human leukemia HEL, K562, HL60 and melanoma WM9 cell lines via MTT method. The bioassay results show that these derivatives possess good inhibitory activities against the four cancer cell lines. Furthermore, these derivatives show better inhibitory activities against K562 than against other cell lines, and most derivatives show better inhibitory activities than the parental material. Moreover, compounds 6a--6i are more active than their inter- mediates 5a--5i when against these ceils. The above results demonstrate the effects of glycosylation on 3-OH of di- osgenin and acetylation of the sugar moiety on their antitumor activities.
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