Enzyme-catalyzed direct three-component aza-Diels–Alder reaction using lipase from Candida sp.99–125

作     者：Dong-Hang Yin Wei Liu Zhi-Xiang Wang Xin Huang Jing Zhang De-Chun Huang 

作者机构：Department of Pharmaceutical Engineering China Pharmaceutical University Department of Energy and Mechanical Engineering Nanjing Normal University 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2017年第28卷第1期

页      面：153-158页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：supported in part by the Natural Science Foundation of Jiangsu Province (No. BK2012763) the Fundamental Research Funds of the Central Universities from the Ministries of Education and Finance of China (No. ZD2014YX0027) 

主　　题：Aza-Diels-Alder reaction Lipase Catalysis Candida sp. 99-125 Azabicyclo [2.2.2] octan-5-one 

摘      要：The direct three-component aza-Diels–Alder reaction was conducted with lipase as a catalyst for the first time. Under the optimized conditions, the aza-Diels–Alder reaction catalyzed by lipase from Candida sp.99–125 provided the products in moderate to excellent yields. Meanwhile, the endo/exo ratio reached up to 88：12.