Practical approach to 2-thioxo-2,3-dihydroquinazolin-4(1H)-one via dithiocarbamate–anthranilic acid reaction

作     者：Najmedin Azizi Mahtab Edrisi 

作者机构：Department of Green Chemistry Chemistry & Chemical Engineering Research Center of Iran P.O. Box 14335-186 Tehran Iran 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2017年第28卷第1期

页      面：109-112页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：the Chemistry and Chemical Engineering Research Center of Iran is gratefully appreciated 

主　　题：Dithiocarbamate Anthranilic acid 2-Thioxo-2,3-dihydroquinazolin- 4(1H)-one 2-Aminobenzoic acid 2-Aminobenzamide lsatoic anhydride 

摘      要：A practical and straightforward protocol has been developed for the preparation of 2-thioxo-2,3-dihydroquinazolin-4（1H）-one derivatives from dithiocarbamate chemistry. The method involves the reaction of anthranilic acid derivatives（2-aminobenzoic acid, 2-aminobenzamide and isatoic anhydride）with various dithiocarbamate derivatives using ethanol as solvent. The main advantages of this protocol include practical simplicity, good to high yields, and ease of product isolation, purification and cheapness of the solvent.