尿8-羟基脱氧鸟苷水平作为评估帕金森病进展的生物学标记物
Urinary 8-hydroxydeoxyguanosine levels as a biomarker for progression of Parkinson disease作者机构：Department of Neurology Juntendo Univ. School of Medicine 2-1-1 Hongo Bunkyo Tokyo 113-8421 Japan Dr.
出 版 物：《世界核心医学期刊文摘（神经病学分册）》 (Digest of the World Core Medical Journals:Clinical Neurology)
年 卷 期：2005年第1卷第9期
页 面：50-50页
学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学]
主 题：帕金森病 脱氧鸟苷 生物学标记物 氧化应激 正常受试者 病程发展
摘 要：8-Hydroxydeoxyguanosine (8-OHdG) has been used to evaluate oxidative stress. The authors investigated urinary 8-OHdG levels in 72 patients with Parkinson d isease (PD) and in normal and disease control groups. The mean urinary 8-OHdG i ncreased with the stage of PD and was not influenced by the current dose of DOPA . Our results suggest that urinary 8-OHdG is a potentially useful biomarker for evaluating the progression of PD.
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