Upgrading the definition of early gastric cancer: better staging means more appropriate treatment

作     者：Luca Saragoni 

作者机构：Department of Pathology G.B.Morgagni-L.Pierantoni Hospital 

出 版 物：《Cancer Biology & Medicine》 (癌症生物学与医学（英文版）)

年 卷 期：2015年第12卷第4期

页      面：355-361页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Early gastric cancer(EGC) definition diagnosis prognosis treatment 

摘      要：Since Murakami defined early gastric cancer(EGC) as a carcinoma limited to the gastric mucosa and/or submucosa regardless of the lymph node status, several authors have focused on the most influential histopathological parameters for predicting the development of lymph node metastases by considering the lymph node status as an important prognostic factor. A few authors have also considered the depth of invasion as one of the keys to explaining the existence of subgroups of patients affected by EGC with poor prognoses. In any case, EGC is still considered an initial phase of tumor progression with good prognosis. The introduction of modern endoscopic devices has allowed a precise diagnosis of early lesions, which can lead to improved definitions of tumors that can be radically treated with endoscopic mucosal resection or endoscopic submucosal dissection(ESD). Given the widespread use of these techniques, the Japanese Gastric Cancer Association( JGCA) identified in 2011 the standard criteria that should exclude the presence of lymph node metastases. At that time, EGCs with nodal involvement should have been asserted as no longer fitting the definition of an early tumor. Some authors have also demonstrated that the morphological growth pattern of a tumor, according to Kodama s classification, is one of the most important prognostic factors, thereby suggesting the need to report it in histopathological drafts. Notwithstanding the acquired knowledge regarding the clinical behavior of EGC, Murakami s definition is still being used. This definition needs to be upgraded according to the modern staging of the disease so that the appropriate treatment would be selected.