Comparison of effect of granules and herbs of Bu-Shen-Yi-Qi-Tang on airway inflammation in asthmatic mice

作     者：Wei Ying Lyu Yubao Li Mihui Luo Qingli Sun Jing Liu Feng Lin Yanhua Chen Meixia Mammat Nurahmat Muhammadian Abduwaki Dong Jingcheng 

作者机构：Department of Integrative Medicine Huashan Hospital Fudan University Shanghai 200040 China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2014年第127卷第22期

页      面：3957-3962页

核心收录：

学科分类：0710[理学-生物学] 090601[农学-基础兽医学] 1002[医学-临床医学] 07[理学] 09[农学] 0906[农学-兽医学] 071002[理学-动物学] 

基　　金：This work was supported by grants from the National Basic Science Program of China (No.2009CB523000) the National Natural Science Program of China (No.81173390/H2902) and the Shanghai Inheritance Base of Yun's Converged Traditional and Western Medicine 

主　　题：Bu-Shen-Yi-Qi-Tang traditional Chinese medicine asthma airway inflammation 

摘      要：Background Bu-Shen-Yi-Qi-Tang （BSYQT）,which is prescribed on the basis of clinical experience,is commonly used in clinics of traditional Chinese medicine （TCM） for asthma *** components of BSYQT include Radix Astragali （RA）,Herba Epimedii （HE） and Radix Rehmanniae （RR）.The aim of this study was to compare the effect of granules and herbs of BSYQT on airway inflammation in asthmatic *** Sixty female BALB/c mice were randomly divided into the normal control （NC） group,asthmatic group （A）,decoction of granules of BSYQT treatment group （GD）,decoction of herbs of BSYQT treatment group （HD）,and dexamethasone treatment group （DEX）.The mouse asthmatic model was induced by ovalbumin （OVA） sensitization and *** and HD of BSYQT as well as DEX were prepared and administered by intragastric *** hyperresponsiveness （AHR） to methacholine （Mch）,lung histopathology analysis,inflammatory mediators in serum （IL-4,IL-5,IL-17A,IFN-γ,and eotaxin） and in lung （IL-4,IL-5,IFN-γ,and eotaxin） were selected for investigation and *** Both GD and HD treatment could decrease airway resistance （RL） and increase dynamic compliance （Cdyn） to Mch compared with the A group （P 0.05）.HD treatment was more effective in RL reduction than Mch at doses of 3.125 and 6.25 mg/ml （P 0.05） and in Cdyn increase at Mch doses of 6.25 and 12.5 mg/ml （P 0.05）.There were no marked differences in RL reduction and Cdyn improvement between mice in HD and DEX groups （P 0.05）.Both GD and HD treatment markedly attenuated lung inflammation （P 0.05）,and HD treatment demonstrated more significant therapeutic function in alleviating lung inflammation than that of GD and DEX treatment （P 0.05）.Both GD and HD treatment resulted in a significant reduction in IL-4 and IL-17A levels and an increase in the IFN-γ level in serum compared with the A group （P 0.05）.The effect of HD in lowering the IL-4 and IL-17A level was significantly greater than that of GD （P 0.05）,and wa