Effect of Atipamzole on Fos Protein Expression Induced by Telazol/ Xylazine in Rat Cerebral Cortex and Thalamencephal

作     者：Yin Bai-shuang Gao Li Fu Lian-jun LI Hong-jin Wang Hong-bin 

作者机构：Department of Veterinary Science College of Jilin Agriculture Science and Technology Jilin 132101 Jilin China Key Laboratory of Preventive Veterinary Medicine Jilin 132101 Jilin China College of Veterinary Medicine Northeast Agricultural University Harbin 150030 China 

出 版 物：《Journal of Northeast Agricultural University(English Edition)》 (东北农业大学学报（英文版）)

年 卷 期：2016年第23卷第4期

页      面：61-66页

学科分类：090601[农学-基础兽医学] 09[农学] 0906[农学-兽医学] 

基　　金：Supported by the National Natural Science Foundation of China(31302150 31272617 and 31001092) 

主　　题：atipamzole tclazol xylazine Fos brain 

摘      要：The aim of the study was to assess effect of the atipamezolc on talezol/xylazine induced expression of c-fos in rat brain. Rats were injected with the mixture of 13.81 mg· kg^-1 telazol and 5.21 mg· kg^-1 xylazine, following 10 min later 0.522 mg· kg^-1 atipamezole injected, and then the cerebral cortex and thalamencephal were removed at 1 h after injected. Level of Fos protein was measured in the brain tissue by westem-blot. The results revealed that telazol/xylazine induction Fos protein expression in the thalamencephal and cerebral cortex during the period of anesthesia, atipamezole attenuated tclazol/ xylazine induction Fos protein expression in the thalamencephal and cerebral cortex. The results indicated that atipamezolc could inhibite telazol/xylazine-induced c-los expression in the rat brain, and played a protective role of neuronal injury.