Spatial signalling mediated by the transforming growth factor-β signalling pathway during tooth formation
Spatial signalling mediated by the transforming growth factor-β signalling pathway during tooth formation作者机构：State Key Laboratory of Oral Diseases West China Hospital of Stomatology Sichuan University West China School of Stomatology Sichuan University Guanghua School of Stomatology Hospital of Stomatology Department of Endodontics Guangdong Provincial Key Laboratory of Stomatology Sun Yat-sen University
出 版 物：《International Journal of Oral Science》 (国际口腔科学杂志（英文版）)
年 卷 期：2016年第8卷第4期
页 面：199-204页
核心收录：
基 金：supported by NSFC grant 81371136 to Xue-Dong Zhou NSFC grant 81470711 to Li-Wei Zheng and grant 2015TD0011 to Ling Ye
主 题：positional information transforming growth factor-13 signalling pathway tooth development
摘 要：Tooth development relies on sequential and reciprocal interactions between the epithelial and mesenchymal tissues, and it is continuously regulated by a variety of conserved and specific temporal-spatial signalling pathways. It is well known that suspensions of tooth germ cells can form tooth-like structures after losing the positional information provided by the epithelial and mesenchymal tissues. However, the particular stage in which the tooth germ cells start to form tooth-like structures after losing their positional information remains unclear. In this study, we investigated the reassociation of tooth germ cells suspension from different morphological stages during tooth development and the phosphorylation of Smad2/3 in this process. Four tooth morphological stages were designed in this study. The results showed that tooth germ cells formed odontogenic tissue at embryonic day （E） 14.5, which is referred to as the cap stage, and they formed tooth-like structures at E16.5, which is referred to as the early bell stage, and E18.5, which is referred to as the late bell stage. Moreover, the transforming growth factor-β signalling pathway might play a role in this process.
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