Catalyst-free hydrochlorination protocol for terminal arylalkynes with hydrogen chloride

作     者：Cai-Xia Xu Cun-Hua Ma Fu-Rong Xiao Hong-Wei Chen Bin Dai 

作者机构：School of Chemistry and Chemical EngineeringShihezi University/Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2016年第27卷第11期

页      面：1683-1685页

核心收录：

学科分类：07[理学] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：financial support from the National Basic Research Program of China(973 Program,No.2012CB720300) the Applied Basic Research Program of Bingtuan(No.2015AG001) the High-level Talent Scientific Research Project of Shihezi University(No.RCZX201405) 

主　　题：Hydrochlorination Arylalkynes Vinyl chlorides Catalyst free Markovnikov addition 

摘      要：We present a simple and straightforward protocol for hydrochlorination of terminal arylalkynes to vinyl chlorides using hydrogen chloride under mild reaction conditions. This protocol does not involve any metal catalysts or additives. It is simple, inexpensive, and easy to prepare, and exhibits good reaction activity. The hydrochlorination proceeds smoothly to yield unique regioselective products via the Markovnikov addition rule.