Evolution of Proinflammatory Cytokines in Hepatocellular Carcinoma Patients Undergoing Orthotopic Liver Transplantation
Evolution of Proinflammatory Cytokines in Hepatocellular Carcinoma Patients Undergoing Orthotopic Liver Transplantation作者机构：Tianjin Institute of Urology Tianjin Medical University Tianjin 300211 China Department of Anesthesia Tianjin Medical University Cancer Institute and Hospital Tianjin 300060 China Orient Organ Transplant Center First Central Clinic Institute of Tianjin Medical University Key Lab for Critical Care Medicine of the Ministry of Health Tianjin 300192 China.
出 版 物：《Clinical oncology and cancer researeh》 (CLINICAL ONCOLOGY AND CANCER RESEARCH)
年 卷 期：2011年第8卷第1期
页 面：38-41页
核心收录：
学科分类：090603[农学-临床兽医学] 08[工学] 09[农学] 0906[农学-兽医学] 0901[农学-作物学] 0836[工学-生物工程] 090102[农学-作物遗传育种]
主 题：liver transplantation carcinoma hepatocellular reperfusion cytokines
摘 要：OBJECTIVE To analyze the expression and levels of serum proinflammatory cytokines including tumor necrosis factor alpha （TNF-α）, and interleukin （IL）-6 in patients with hepatocellular carcinoma （HCC）, who received orthotopic liver transplantation （OLT）.METHODS The blood samples of 20 consecutive HCC patients who underwent liver transplantation were detected and analyzed for the clinical serum biochemical parameters, TNF-α and *** samples were drawn from the radial artery at planned time points： preoperatively, intraoperatively, and *** of serum TNF-α and IL-6 were detected with enzymelinked immunosorbent assay （ELISA）.RESULTS The levels of serum TNF-αand IL-6 increased significantly at reperfusion phase compared with those detected preoperatively （P 〈 0.01）, and the level of serum IL-6 remained significantly higher until the third day after the liver transplantation. There was a significant correlation between TNF-αand IL-6 （P〈0.001）.CONCLUSION This research into the effects of the proinflammatory cytokines on liver transplantation has provided new insights into the mechanisms of ischemia and reperfusion injury to OLT.
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