C30F12.4 influences oogenesis, fat metabolism, and lifespan in C. elegans

作     者：Lu Wang Fei Xu Guishuan Wang Xiaorong Wang Ajuan Liang Hefeng Huang Fei Sun 

作者机构：International Peace Maternity & Child Health Hospital Shanghai Key laboratory for Reproductive Medicine School of Medicine Institute of Embryo-Fetal Original Adult Disease Shanghai Jiaotong University Shanghai 200030 China School of Life Sciences University of Science and Technology of China Hefei 230026 China 

出 版 物：《Protein & Cell》 (蛋白质与细胞（英文版）)

年 卷 期：2016年第7卷第10期

页      面：714-721页

核心收录：

学科分类：0710[理学-生物学] 090502[农学-动物营养与饲料科学] 07[理学] 0905[农学-畜牧学] 09[农学] 071007[理学-遗传学] 0901[农学-作物学] 090102[农学-作物遗传育种] 

基　　金：国家自然科学基金 国家973计划 Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant 

主　　题：C30F12.4 oogenesis fat metabolism,lifespan 

摘      要：Reproduction, fat metabolism, and longevity are inter- twined regulatory axes; recent studies in C. elegans have provided evidence that these processes are directly coupled. However, the mechanisms by which they are coupled and the reproductive signals modu- lating fat metabolism and lifaspan are poorly under- stood. Here, we find that an oogenesis-enriched gene, c30PI2.4, is specifically expressed and located in germ cells and early embryos; when the gene is knocked out, oogenesis is disrupted and brood size is decreased. In addition to the reproductive phenotype, we find that the loss of c30f12.4 alters fat metabolism, resulting in decreased fat storage and smaller lipid droplets. Mean- while, c30f12.4 mutant worms display a shortened lifaspan. Our results highlight an important role for c30f12.4 in regulating reproduction, fat homeostasis, and aging in C. elegans, which helps us to better understand the relationship between these processes.