Cavity Control of Prefoldin Nano Actuator (PNA) by Temperature and pH

作     者：Ali Shokuhfar Ali Ghaffari Reza Hasanzadeh Ghasemi 

作者机构：Department of Mechanical Engineering K.N. Toosi University of Technology 

出 版 物：《Nano-Micro Letters》 (纳微快报（英文版）)

年 卷 期：2012年第4卷第2期

页      面：110-117页

核心收录：

学科分类：0808[工学-电气工程] 0809[工学-电子科学与技术（可授工学、理学学位）] 07[理学] 0817[工学-化学工程与技术] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0702[理学-物理学] 

主　　题：Prefoldin Nano Actuator(PNA) Cavity control Molecular Dynamics GROMACS 

摘      要：A molecular dynamics study to investigate the cavity control of Prefoldin based bio nano actuator is presented in this paper. Prefoldin is a molecular chaperone with a jellyfish-like structure containing six long coiled-coil tentacles and a large central cavity. We took the temperature and p H of the medium into account,and analyzed the conformational flexibility of the Prefoldin nano actuator in details. Results show that the prefoldin is a very flexible protein, the conformational state of which appears to depend on the temperature and p H values of the medium. In fact, combining these two control parameters, a suitable environment is provided to capture nano cargoes with specific dimensions. These properties of Prefoldin actuator can be used for drug delivery in the body.