Association of ALOX5AP with ischemic stroke in eastern Chinese

作     者：Yao Wang Gan-nan Wang Hao Sun Chen Chen Hang Xiao Jin-song Zhang 

作者机构：Department of Emergency MedicineFirst Affiliated HospitalNanjingMedical University Jiangsu Province Center for Disease Control Laboratory of NeurotoxicologySchool of Public HealthNanjing Medical University 

出 版 物：《World Journal of Emergency Medicine》 (世界急诊医学杂志（英文）)

年 卷 期：2012年第3卷第2期

页      面：108-113页

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：supported by Research Foundation of Jiangsu Province Hygiene Committee(H201005) 

主　　题：5-1ipoxygenase activating protein (ALOX5AP) Leukotrienes (LTs) Trial of Org10172 in Acute Stroke Treatment (TOAST) Single nucleotide polymorphisms (SNPs) Ischemic stroke 

摘      要：BACKGROUND：5-1ipoxygenase protein （ALOX5AP） has been recognized as a susceptibility gene for stroke and coronary artery diseases. The present study was to explore the role of this gene in the eastern Chinese patients with ischemic ***： Using a case-control design, we studied 658 patients with ischemic stroke and 704 unrelated population-based controls who were age- and sex-matched. The 658 patients were classified by the Trial of Org 10172 in Acute Stroke Treatment （TOAST）. Two single-nucleotide polymorphisms （SNPs） covering ALOX5AP were genotyped. RESULTS： The genotype frequencies of TG of the SNPs rs17222919 located in the promoter of the ALOX5AP gene were significantly higher in patients with ischemic stroke than in controls （OR＊=1.34, 95%C1＊=1.02-1.75）, especially in patients with ischemic stroke caused by small-artery occlusion （SAO） （OR＊=1.40, 95%C1＊=1.02-1.93）. Meanwhile, the genotype frequencies of TG and TG/ GG were higher in female patients than in the controls. After specification, the genotype frequencies of TG and TG/GG were higher in the patients than in controls with hypertension. The genotype frequencies of AG and AG/GG of the SNPs rs9579646 located in the intron of the ALOX5AP gene were higher in the controls than in the patients. After specification, the genotype frequencies of TG were higher in the controls than patients without hypertension. CONCLUSIONS： The present study suggests that sequence variants in the ALOX5AP gene are significantly associated with ischemic stroke.