Targeting lysophospholipid signaling as a therapeutic approach towards improved peripheral nerve regeneration

作     者：Fabian Szepanowski Bernd C.Kieseier 

作者机构：Department of NeurologyMedical FacultyHeinrich-Heine-University 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2016年第11卷第11期

页      面：1754-1755页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100204[医学-神经病学] 10[医学] 

主　　题：FTY LPA AMP 

摘      要：Peripheral nerve injury causes a partial or total loss of motor and sensory functions as a result of axonal disruption and subsequent axonal disintegration as well as denervation distal from the point of injury. Although peripheral nerves are, in contrast to the central nervous system, able to regenerate and reinnervate, functionality is not always restored completely due to insufficient reinnervation or remyelination, and injury may result in sequelae such as neuropathic pain. The degenerative processes following peripheral nerve injury are generally referred to as Wallerian degeneration （Gaudet et al., 2011）.