Etiologic factors of gastric cardiac adenocarcinoma among men in Taiwan

作     者：Mei-Ju Chen Deng-Chyang Wu Jia-Ming Lin Ming-Tsang Wu Fung-Chang Sung 

作者机构：Institute of Environmental HealthNational Talwan U-niversity College of Public Health 17 Xuzhou Road Zhongzheng District Taipei City 100 Taiwan China Department of Nursing Chung Hwa University of Medical Technology 89 Wen-Hwa-1 st Street Jen-Te Hsiang Tainan Hsien 717 Taiwan China Department of Internal Medicine Kaohsiung Medical University Hospital 100 Tz-You 1st Road Kaohsiung City 807 Taiwan China Faculty of Medicine College of Medicine Kaohsiung Medical University I00 Shih-Chuan 1st Road Kaohsiung City 807 Taiwan China Research of Excellence for Environmental Medicine Kaohsiung Medical University 100 Shih-Chuan 1st Road Kaohsiung City 807 Taiwan China Department of Family Medicine and Graduate Institute of Occupational Safety and Health Kaohsiung Medical University Hospital 100 Tz-You 1st Road Kaohsiung City 807 Taiwan China Institute of Environmental Health China Medical University College of Public Health 91 Hsueh-Shih Road Taichung 404 Taiwan China 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2009年第15卷第43期

页      面：5472-5480页

核心收录：

学科分类：090603[农学-临床兽医学] 0303[法学-社会学] 12[管理学] 1204[管理学-公共管理] 03[法学] 09[农学] 0906[农学-兽医学] 030301[法学-社会学] 

基　　金：Supported by China Medical University Republic of China for Project Grant(CMU-EM01 and CMU94-074) 

主　　题：Gastric cardiac adenocarcinoma Helicobacterpylori Diet Obesity Gastroesophageal reflux disease Cigarette smoking Family history 

摘      要：AIM:To elucidate etiologic associations between Helicobacter pylori(H pylori),lifestyle,environmental factors and gastric cardiac adenocarcinoma(GCA)among men. METHODS:A hospital-based case-control study was conducted in Taiwan from 2000 to *** cases were newly confirmed as primary *** controls were selected matching with age,sex,and admission date to each *** were informedof potential risk factors with a structured question- naire by trained interviewers during hospitalization and provided a blood sample for the determination of H pylori *** ratio(OR)and 95%confidence interval(95%CI)were used to evaluate risk,and a multivariate conditional logistic regression model was performed. RESULTS:All participants recruited for this study were men,consisting of 41 cases and 205 *** of the univariate analysis showed that significant factors associated with the etiology of GCA included H pylori(OR =2.69,95%CI=1.30-5.53),cigarette smoking(OR= 2.28,95%CI=1.05-4.96),working or exercising after meals(OR=3.26,95%CI=1.31-8.11),salted food (OR=2.51,95%CI=1.08-6.11),fresh vegetables(OR =0.28,95%CI=0.09-0.80),fruits(OR=0.19,95% CI=0.04-0.89),and rice as principal food(OR=0.53, 95%CI=0.30-0.85).Multivariate conditional logistic regression models indicated that a significantly elevated risk of contracting GCA was associated with working or exercising after meals(OR=3.18,95%CI=1.23-9.36) and H pylori infection(OR=2.93,95%CI=1.42-6.01). In contrast,the consumption of fresh vegetables(OR =0.22,95%CI=0.06-0.83),fruits(OR=0.28,95% CI=0.09-0.79)and rice as principal food(OR=0.48, 95%CI=0.24-0.93)remained as significant beneficial factor associated with GCA. CONCLUSION:Working or exercising after meals and H pylori infection increase the risk of GCA,but higher intakes of rice,fresh vegetables and fruits reduce the risk.