Evaluation of pharmacokinetics underlies the collaborated usage of lamivudine and oxymatrine in beagle dogs

作     者：Zhenbao Li Lei Shang Chang Liu Panqin Ma Chunnuan Wu Wenjuan Zhang Yinghua Sun Yongjun Wang Xiaohong Liu Jin Sun 

作者机构：School of PharmacyShenyang Pharmaceutical UniversityNo.103Wenhua RoadShenyang 110016China School of PharmacyChina Medical UniversityNo.77 Puhe RoadShenyang North New AreaShenyang 110122China Kangya of Ningxia Pharmaceuticals Co.LtdNo.57 FuanWest LaneYinchuan 750002China Tianjin Medical University Cancer HospitalTianjin 300060China Municipal Key Laboratory of BiopharmaceuticsSchool of PharmacyShenyang Pharmaceutical UniversityNo.103Wenhua RoadShenyang 110016China 

出 版 物：《Asian Journal of Pharmaceutical Sciences》 (亚洲药物制剂科学（英文）)

年 卷 期：2016年第11卷第5期

页      面：641-647页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 1002[医学-临床医学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：the National Natural Science Foundation of China(Nos.30901996,81173009 and 81302722) the General Project in Education Department of Liaoning Province(No.L2013390) the Specific Science Foundation of Shenyang Pharmaceutical University(Nos.ZCJJ2014409 and ZCJJ2013402) 

主　　题：Oxymatrine Lamivudine Matrine Beagle dog Intravenous/oral regime 

摘      要：Combinational therapy of lamivudine and oxymatrine has been employed in the battle against hepatitis B virus in clinical setting. However, the pharmacokinetic behavior of the drug or active metabolism in intravenous/oral co-administration regime is poorly investigated. Herein,we evaluated the pharmacokinetic characteristic through a tailor-designed 3 way crossoverLatin square experiment in adult male beagle dogs. Six dogs were randomly treated by intravenous administration of lamivudine(2.5 mg/kg), oxymatrine(15 mg/kg) and combinational dosage, named as intravenous regime. Meanwhile the other six dogs were orally administrated with lamivudine(2.5 mg/kg), oxymatrine(15 mg/kg) and combinational dosage,named as oral regime. The pharmacokinetic feature in simultaneous oral treatment appeared to have no significant difference when compared with individual administration,even including matrine, the active metabolite of oxymatrine. In intravenous regime, the main pharmacokinetic parameters of simultaneous administration were nearly consistent with intravenous regime remedy. The collaborated application of lamivudine and oxymatrine contributed to non-distinctive pharmacokinetic fluctuations of beagle dogs in intravenous/oral regime, compared with individual employment, which established a vital base for the clinical co-administration against hepatitis B. Furthermore, the present study demonstrated that the determination of pharmacokinetics between combinational and individual therapy might assist in the development of drug compatibility in clinical therapy.