Translational pain research: Evaluating analgesic effect in experimental visceral pain models

作     者：Anne Estrup Olesen Trine Andresen Lona Louring Christrup Richard N Upton 

作者机构：Mech-Sense Department of Gastroenterology Aalborg Hospital Aarhus University Hospital 9000 Aalborg Denmark Center for Sensory-Motor Interactions Department of Health Science and Technology Aalborg University 9000 AalborgDenmark Center for Sensory-Motor Interactions Department of Health Science and Technology Aalborg University 9000 Aalborg Denmark Faculty of Pharmaceutical Sciences University of Copenhagen Denmark Discipline of Anaesthesia and Intensive Care Royal Adelaide Hospital University of Adelaide Adelaide South Australia Australia 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2009年第15卷第2期

页      面：177-181页

核心收录：

学科分类：1006[医学-中西医结合] 1002[医学-临床医学] 100602[医学-中西医结合临床] 10[医学] 

主　　题：Visceral pain Analgesics Pharmacokinetics Pharmacodynamics 

摘      要：Deep visceral pain is frequent and presents major challenges in pain management, since its pathophysiology is still poorly understood. One way to optimize treatment of visceral pain is to improve knowledge of the mechanisms behind the pain and the mode of action of analgesic substances. This can be achieved through stand-ardized experimental human pain models. Experimental pain models in healthy volunteers are advantageous for evaluation of analgesic action, as this is often diff icult to assess in the clinic because of confounding factors such as sedation, nausea and general malaise. These pain models facilitate minimizing the gap between knowledge gained in animal and human clinical studies. Combining experimental pain studies and pharmacokinetic stud- ies can improve understanding of the pharmacokinetic-pharmacodynamic relationship of analgesics and, thus, provide valuable insight into optimal clinical treatment of visceral pain. To improve treatment of visceral pain, it is important to study the underlying mechanisms of pain and the action of analgesics used for its treatment. An experimental pain model activates different modalities and can be used to investigate the mechanism of action of different analgesics in detail. In combination with pharmacokinetic studies and objective assessment such as electroencephalography, new information re-garding a given drug substance and its effects can be obtained. Results from experimental human visceral pain research can bridge the gap in knowledge between animal studies and clinical condition in patients suffering from visceral pain, and thus constitute the missing link in translational pain research.