Biomaterial property-controlled stem cell fates for cardiac regeneration
作者机构：Department of Materials Science and EngineeringThe Ohio State UniversityColumbusOHUSA
出 版 物：《Bioactive Materials》 (生物活性材料（英文）)
年 卷 期：2016年第1卷第1期
页 面：18-28页
学科分类：1001[医学-基础医学(可授医学、理学学位)] 10[医学]
基 金：This work was supported by National Science Foundation(1006734 and 1160122) National Institutes for Health(R01HL124122) American Heart Association(15GRNT25830058 and 13GRNT17150041) National Science Foundation of China(81471788) Institute for Materials Research seed grant at The Ohio State University
主 题：Myocardial infarction Cardiac tissue engineering Cardiac differentiation Biomaterials Stem cell fate
摘 要：Myocardial infarction(MI)affects more than 8 million people in the United States *** to the insufficient regeneration capacity of the native myocardium,one widely studied approach is cardiac tissue engineering,in which cells are delivered with or without biomaterials and/or regulatory factors to fully regenerate the cardiac ***,in vitro cardiac tissue engineering focuses on using biomaterials as a reservoir for cells to attach,as well as a carrier of various regulatory factors such as growth factors and peptides,providing high cell retention and a proper microenvironment for cells to migrate,grow and differentiate within the scaffolds before *** studies have shown that the full establishment of a functional cardiac tissue in vitro requires synergistic actions between the seeded cells,the tissue culture condition,and the biochemical and biophysical environment provided by the biomaterials-based *** electrical stimulation and mechanical stretch during the in vitro culture can induce the ordered orientation and differentiation of the seeded *** the other hand,the various scaffolds biochemical and biophysical properties such as polymer composition,ligand concentration,biodegradability,scaffold topography and mechanical properties can also have a significant effect on the cellular processes.
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