Secondary metabolites and their biological activities in Indonesian soft coral of the genus Lobophytum

作     者：Masteria Yunovilsa Putra Tutik Murniasih Respati Tri Swasono Joko Tri Wibowo Annissa Nur Cahya Saputri Meilia Rahma Widhiana Irma Shita Arlyza 

作者机构：Research Center for Oceanography Indonesian Institute of Sciences Jl.Pasir Putih I Department of Chemistry Faculty of Mathematics and Natural Sciences Universitas Gadjah Mada 

出 版 物：《Asian Pacific Journal of Tropical Biomedicine》 (亚太热带生物医学杂志（英文版）)

年 卷 期：2016年第6卷第11期

页      面：909-913页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：Supported by the Coral Reef Rehabilitation and Management Program–Coral Triangle Initiative(Grant No.COREMAP CTI-LIPI 2016 No.10876401/ADB LOAN No.3094-INO) 

主　　题：Ocean Indonesia Natural products Biological activities 

摘      要：Objective: To investigate the antioxidant, antibacterial, antimalarial activities and cytotoxicity of the n-hexane, ethyl acetate, n-butanol, and aqueous fractions from a crude extract of Lobophytum ***: This organism was collected from the Selayar Islands(South Sulawesi). The antioxidant activity was performed by the 1,1-diphenyl-2-picryl hydrazyl radical scavenging method. All fractions from the crude extract of Lobophytum sp. were examined for their cytotoxicity using the brine shrimp lethality bioassay and heme polymerization inhibitory activity assay for antimalarial ***: It was found that the ethyl acetate, n-butanol and aqueous fractions exhibited heme polymerization inhibitory activity with IC_(50) values of 11.7, 14.3 and 12.0 mg/m L,respectively, while the n-butanol fraction showed moderate antioxidant activity and cytotoxicity with IC_(50) values of 150.00 and 92.74 mg/m L, ***: This study provides information on antioxidant, antibacterial and antimalarial activities as well as the cytotoxicity of all fractions from the crude extract of Lobophytum sp. This is a new report of antimalarial substances derived from Lobophytum sp.