High risk cutaneous squamous cell carcinoma of the head and neck

作     者：Stephen Y. Kang Amanda E. Toland Kang Stephen Y.;Toland Amanda E.

作者机构：Department of 0tolaryngology-Head and Neck Surgery The 0hio State University Wexner Medical Center The James Cancer Hospital and Solove Research Institute Columbus 0H USA Department of Molecular Virology Immunology&Medical Genetics Department of Internal Medicine The 0hio State University Wexner Medical Center Columbus 0H USA 

出 版 物：《World Journal of Otorhinolaryngology-Head and Neck Surgery》 (世界耳鼻咽喉头颈外科杂志（英文）)

年 卷 期：2016年第2卷第2期

页      面：-页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：The authors thank Diane Dziewatkowski for her assistance in preparation of the manuscript 

主　　题：Squamous cell carcinoma Cutaneous Head and neck cancer 

摘      要：The majority of patients with head and neck cutaneous squamous cell carcinoma (cSCC) are successfully treated with surgical treatment of the primary site. While only a minor-ity of patients is at risk for regional metastasis, these patients have significantly worse out-comes. Tumor and patient factors that place patients at high risk for development of regional metastasis have been identified. Advancing treatment of cSCC requires identifying and escalating treatment in this high risk patient population, while avoiding overtreatment of the majority of cSCC patients that do not develop regional metastasis. Sentinel lymph node biopsy has emerged as a promising technique in cSCC to detect micrometastasis and allow early surgical treatment of regional disease. Future directions involve genomic characteriza-tion of metastatic and nonmetastatic cSCC to identify genomic alterations causing metastasis that may be used to predict disease behavior. Copyright a 2016 Chinese Medical Association. Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. This is an open access article under the CC BY-NC-ND license (http://***/licenses/by-nc-nd/4.0/).