Functional Annotation of Metastasis-associated MicroRNAs of Melanoma： A Meta-analysis of Expression Profiles

作     者：Jing-Yi Li Li-Li Zheng Ting-Ting Wang Min Hu Li Jing-Yi;Zheng Li-Li;Wang Ting-Ting;Hu Min

作者机构：Department of StomatologyChinese People's Liberation Army General HospitalBeijing 100853China Department of Endocrinology and MetabolismThe First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450000China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2016年第129卷第20期

页      面：2484-2490页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Expression Profiles Melanoma Metastasis MicroRNA 

摘      要：Background：Melanoma is a type of cancer that develops from the pigment-containing *** now,its pathological mechanisms remain largely *** aim of this study was to identify metastasis-related microRNA （miRNAs） and gain an understanding of the biological functions in the metastasis of ***：We searched the PubMed and Gene Expression Omnibus database to collect miRNA expression profiling datasets about melanoma,with key words of＂melanoma＂,＂miRNA＂,＂microarray＂,and ＂gene expression profiling＂.Only the original experimental works published before June 2016 for analyzing the metastasis of melanoma were retained,other nonhuman studies,reviews,and meta-analyses were *** performed a meta-analysis to explore the differentially expressed miRNA between metastatic and nonmetastatic ***,we predicted target genes of the miRNAs to study their biological roles for these ***：We identified a total of 63 significantly differentially expressed miRNAs by meta-analysis of the melanoma expression profiling *** regulatory network constructed by using these miRNAs and the predicted targets identified several key genes involved in the metastasis of *** annotation of these genes indicated that they are mainly enriched in some biological pathways such as mitogen-activated protein kinase signaling pathway,cell junction,and focal ***：By collecting the miRNA expression datasets from different platforms,multiple biological markers were identified for the metastasis of *** study provided novel insights into the molecular mechanisms underlying this disease,thereby aiding the diagnosis and treatment of the disease.