Diagnosis, treatment and prognosis of rhabdomyolysis

作     者：李捷 黄雨晴 冯颖青 

作者机构：Department of CardiologyGuangdong Cardiovascular InstituteGuangdong Provincial Key Laboratory of Coronary Heart Disease PreventionGuangdong General HospitalGuangdong Academy of Medical Sciences 

出 版 物：《South China Journal of Cardiology》 (岭南心血管病杂志（英文版）)

年 卷 期：2016年第17卷第3期

页      面：133-138页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by the grants from Guangdong Natural Science Foundation(No.2015A030313660) the Technology Project Foundation of Guangzhou(No.2014y2-00140/No.1563000381) the Technology Project Foundation of Guangdong Province(No.2014B020212008/No.2007B031500010) 

主　　题：rhabdomyolysis lipid-lowering drugs statins prognosis 

摘      要：Background Statins are lipid-lowering drugs that are used widely around the world to treat and prevent car- diovascular diseases. Rare, but potentially fatal, cases of rhabdomyolysis （RM） have linked to the use of statins, especially in the presence of other risk factors. Methods We retrospectively analyzed the causes, clinical char- acteristics, treatments and prognosis of RM patients who were hospitalized between January 2005 and March 2016 at the Guangdong General Hospital, China. A total of 16 patients were included in the study （12 males and four females, mean age 60.69 years）. Amongst the patients, there were three cases of coronary heart disease, eight cases of dilated cardiomyopathy, six cases of atrial fibrillation, one case of pulmonary embolism, one case of aor- tic dissection, six cases of hypertension and one case of paroxysmal ventricular tachycardia. All patients had some degree of liver and kidney dysfunction, with low hemoglobin and myoglobinuria. Seven patients had a fe- ver and four had relevant neurological signs. All patients had digestive disorders and muscle weakness or pain during their stay in hospital. All patients received renal replacement therapy and 13 were placed on a ventilator to support breathing. Nine patients were eventually improved but seven patients died despite treatment. Results All sixteen cases of RM were associated with lipid-lowering drugs, with 14 patients taking statins and two pa- tients taking fibrates. Conclusions Statins were the main cause of RM in patients with poor prognosis and high mortality rate.