WNK3 Interacts with NCC

作     者：Dexuan Wang Shufang Pan Yixiao Xu Xiaohua Ye Xiaobi Ren Qiyi Zeng 

作者机构：Pediatric Center of Zhujiang Hospital Southern Medical University Department of Pediatrics The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University 

出 版 物：《Science China(Life Sciences)》 (中国科学（生命科学英文版）)

年 卷 期：2016年第59卷第11期

页      面：1189-1191页

核心收录：

学科分类：0710[理学-生物学] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(81200513) Qianjiang Talents Project of Technology Office of Zhejiang Province(2011R10049) Wenzhou Science&Technology Bureau(H20110014) 

主　　题：WNK3 Interacts with NCC Figure 

摘      要：Dear Editor, NCC （Na-Cl cotransporter） is a cotransporter mainly dis- tributed in the distal tubule of the kidney, functioning to reabsorb sodium and chloride ions from the tubular fluid into the cells of the renal distal convoluted tubule. It is a transmembrane protein belonging to the SLC12 cotransporter family of electro-neutral cation-coupled chloride cotransporters, which is closely related to hypertension （Gamba, 2005）. A loss of NCC function can cause Gitelman syndrome, a disease characterized by low blood pressure,