Caffeoylquinic acid derivatives extract of Erigeron multiradiatus alleviated acute myocardial ischemia reperfusion injury in rats through inhibiting NF-kappaB and JNK activations

作     者：ZHANG Zhi-feng REN Xue-cong DONG Geng-ting LUO Pei ZHOU Hua ZHANG Hao 

作者机构：State Key Laboratories for Quality Research in Chinese MedicinesMacao University of Science and Technology Department of Medicinal Natural ProductsWest China School of PharmacySichuan University 

出 版 物：《中国药理学与毒理学杂志》 (Chinese Journal of Pharmacology and Toxicology)

年 卷 期：2016年第30卷第10期

页      面：1006-1006页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：The project supported by the Macao Science and Technology Development Fund(052/2013/A2) 

主　　题：Erigeron multiradiatus caffeoylquinic acid myocardial Ischemia reperfusion inflammation NF-κB JNK 

摘      要：Erigeron multiradiatus(Lindl.)Benth.,has been used in Tibet folk medicine to treat various inflammatory *** aim of this study was to investigate anti-myocardial ischemia and reperfusion(I/R)injury effect of caffeoylquinic acids derivatives of ***(AE)in vivo and to explain underling *** was prepared using the whole plant of *** and contents of 6 caffeoylquinic acid determined through HPLC *** I/R were induced by left anterior descending coronary artery occlusion for 30 min followed by 24 h of reperfusion in *** administration(10,20 and 40 mg·kg-1)inhibited I/R-induced injury as indicated by decreasing myocardial infarct size,reducing of CK and LDH activities and preventing ST-segment depression in dose-dependent *** decreased cardiac tissue levels of pro-inflammatory factors TNF-αand IL-6 and attenuated leukocytes *** was further demonstrated to significantly inhibit I-κB degradation,nuclear translocation of p-65 and phosphorylation of *** results suggested that cardioprotective effect of AE could be due to suppressing myocardial inflammatory response and blocking NF-κB and JNK activation ***,caffeoylquinic acids might be the active compounds in *** on myocardial ischemia and be a potential natural drug for treating myocardial I/R injury.