DUAL ACTION OF SUBSTANCE P IN NOCICEPTION AND PAIN MODULATION AT SPINAL LEVEL

作     者：朱丽霞 黎春元 吉长福 ZHU LIXIA LI CHUNYUAN AND JI CHANGFU (The 1st Department of Physiology, Institute of Acupuncture and Moxibustion, Academy of Traditional Chinese Medicine, Beijing)

作者机构：The 1st Department of Physiology Institute of Acupuncture and Moxibustion Academy of Traditional Chinese Medicine Beijing 

出 版 物：《Science in China,Ser.B》 (中国科学B辑(英文版))

年 卷 期：1987年第30卷第7期

页      面：727-738页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：SPO DUAL ACTION OF SUBSTANCE P IN NOCICEPTION AND PAIN MODULATION AT SPINAL LEVEL 

摘      要：In the present study, the activation of the nociceptive dorsal horn neurons in rats by iontophoretic substance P （SP） has been observed. Thus, the role of SP in spinal nociception is further *** addition, the inhibitory effects of iontophoretic SP on nociceptive response （C response） of dorsal horn neurons can also be observed even in rats that have undergone dorsal half transection of spinal cord. These inhibitory effects can be partially blocked by pretreatment with iontophoretic bicuculline but not by naloxone. It indicates that the SP-induced inhibitory effects on the nociceptive response may be mainly mediated by the presynaptic inhibition in which γ-aminobutyric acid （GABA） may be *** view of the fact that the inhibitory effect of stimulation of nucleus raphe magnus （NRM） on the nociceptive response of dorsal horn neurons in rats depleted of 5-HT with parachlorophenylalanine （pCPA） can be significantly blocked by iontophoretie SP-antagonist, it is supposed that SP may be involve