Inhibitory Effect of Anisodamine on the Neuropathic Hyperalgesia Following Peripheral Nerve Injury (Ⅱ)
Inhibitory Effect of Anisodamine on the Neuropathic Hyperalgesia Following Peripheral Nerve Injury （Ⅱ）作者机构：Institute of Basic Medical Sciences Chinese Academy of Medical Sciences Beijing 100005 PRC Institute of Basic Medical Sciences Chinese Academy of Medical Sciences Beijing 100005 PRC
出 版 物：《Science China Mathematics》 (中国科学:数学(英文版))
年 卷 期：1993年第7期
页 面：824-834页
基 金：This work was supported by Grants from the National Natural Science Foundation of China China Medical Board of New York and Ministry of Public Health China
主 题：nerve injury hyperalgesia neuropathic pain ectopic discharge anisodamine.
摘 要：Aperipheral neuropathy with hyperalgesia and allodynia was produced by loosely tying constrictive ligature around the left sciatic nerve of rats, i.v. injection of anisodamine 20mg/Kg abolished both neuropathic hyperalgesia responses to noxious radiant heat and ectopic discharges generated from the injured region of the nerve. Anisodanime applied either systemically or locally to the damaged area of the nerve not only ceased the spontaneous ectopic discharges recorded from Ato C fibers but also blocked the afferent ectopic discharge elicited by Kchannel blocker, noradrenaline, Caor antidromic stimulation of sciatic nerve proximal to the injured nerve area. The experiments indicated that anisodamine probably possessed a calcium channel blocker-like activity and produced selective block of the new channels in the injured area. It is suggested that anisodamine may be a candidate therapeutic agent in relieving hyperalgesia and allodynia following nerve injury.
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