SYNTHESIS OF METHYLISOAMYLNITROSAMINE FROM ISOAMYLAMINE BY FUNGI(FUSARIUM MONILIFORME)

作     者：季川 李铭新 李金兰 赵守金 王光辉 贺玉珍 Jr CHUAN, LI MINGXIN(MIN-HSIN LI, LI JINLAN ZHAO SHOUJIN(Department of Chemical Etiology and Carcinogenesis, Cancer Institute, Chinese Academy of Medical Sciences, Beijing) WANG GUANGHUI AND HE YUZHEN(Department of Chemical Analysis, Institute of Chemistry, Academia Sinica, Beijing)

作者机构：Department of Chemical Etiology and Carcinogenesis Cancer Institute Chinese Academy of Medical Sciences Beijing Department of Chemical Analysis Institute of Chemistry Academia Sinica 

出 版 物：《Science in China,Ser.B》 (中国科学B辑(英文版))

年 卷 期：1985年第28卷第11期

页      面：1188-1196页

核心收录：

学科分类：07[理学] 0703[理学-化学] 

主　　题：SYNTHESIS OF METHYLISOAMYLNITROSAMINE FROM ISOAMYLAMINE BY FUNGI FUSARIUM MONILIFORME IAA 

摘      要：Methylisoamylnitrosamine, a carcinogenic N-nitroso compound, has been formed in glucose ammonium nitrate medium containing 150 mg of isoamylamine （a primary amine） inoculated with a common fungus （Fusarium moniliforme Sheldon）, to which 400 mg NaNO2 are added after incubation for 7—8 days at 28℃. No such compound has been found in control samples without fungi or isoamylamine. This paper reports a method of experimental synthesis of the nitrosamine by F. moniliforme strains 82—01 and 83—01, using isoamylamine and NaNO2, as well as the analysis of the compound by GC/MS and GC/TEA.