Pre-concentration and determination of amitriptyline residues in waste water by ionic liquid based immersed droplet microextraction and HPLC

作     者：M.T.Hamed Mosavian Z.Es’haghi N.Razavi S.Banihashemi 

作者机构：Chemical Engineering DepartmentFerdowsi University of MashhadMashhadIran Department of ChemistryPayame Noor University19395-4697 TehranIslamic Republic of Iran Chemistry DepartmentFaculty of SciencesFerdowsi University of MashhadMashhadIran 

出 版 物：《Journal of Pharmaceutical Analysis》 (药物分析学报（英文版）)

年 卷 期：2012年第2卷第5期

页      面：361-365页

学科分类：081702[工学-化学工艺] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070302[理学-分析化学] 0703[理学-化学] 

基　　金：The authors wish to acknowledge the useful help of Chemical Engineering Research Lab Ferdowsi University of Mashhad, Engineering Faculty, Chemical Engineering Department, for conducting the experiments 

主　　题：Antidepressant Ionic liquid based immersed droplet microextraction (IL-IDME) High performance liquid chromatography(HPLC) 

摘      要：This paper describes a new approach for the determination of amitriptyline in wastewater by ionic liquid based immersed droplet microextraction （IL-IDME） prior to highperformance liquid chromatography with ultraviolet detection. 1-Hexyl-3-methylimidazolium hexafluorophosphate （[C6MIM][PF6]） was used as an ionic liquid. Various factors that affect extraction, such as volume of ionic liquid, stirring rate, extraction time, pH of the aqueous solution and salting effect, were optimized. The optimal conditions were as follows： microextraction time, 10 min; stirring rate, 720 rpm; pH, 11; ionic drop volume, 100 uL; and no sodium chloride addition. In quantitative experiments the method showed linearity in a range from 0.01 to 10 ug/mL, a limit of detection of 0.004 ug/mL and an excellent pre-concentration factor （PF） of 1100. Finally, the method was successfully applied to the determination of amitriptyline in the hospital wastewater samples.