2003年印第安那州猴痘病毒在接触获感牧羊犬人群中的传播

作     者：Kile J.C. Fleischauer A.T. Beard B. 贺莉 

作者机构：United States Department of Agriculture Landmark Center 1299 Farnam St OmahaNE 68102United StatesDr 

出 版 物：《世界核心医学期刊文摘（儿科学分册）》 (Dkgest of the World Latest Medical Information)

年 卷 期：2006年第2卷第4期

页      面：23-24页

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

主　　题：猴痘病毒 血清转换率 主动监测 家庭成员 

摘      要：Objective: To describe a cluster of human monkeypox cases associated with exposure to ill prairie dogs in a home child care. Design, Setting, Participants: We identified all persons exposed to 2 pet prairie dogs in County A, Indiana; performed active surveillance for symptomatic monkeypox infection; and evaluated the types of exposure that may have resulted in infection. For children who attended the child care where the animals were housed, we also measured the rate of seroconversion to monkeypox virus. Main Outcome Measures: Nine (13% ) of 70 persons exposed to the prairie dogs reported signs and symptoms of monkeypox. Two (40% ) of 5 symptomatic child care attendees reported direct contact with the prairie dogs. Two (13% ) of 15 child care attendees evaluated tested positive for IgM antibodies against orthopoxvirus; both reported symptoms consistent with monkeypox. Results: The risk of symptomatic infection correlated with the time and intensity of animal exposure, which was 100% (4/4) among family members with extensive direct contact, 19% (5/26) among the veterinarian and nonfamily child care attendees with moderate exposure, and 0% (0/40) among school children with limited exposure (P .01). Conclusions: Monkeypox virus was transmitted from ill prairie dogs in a child care and veterinary facilities. The risk of symptomatic infection correlated with the amount of exposure to the prairie dogs. Although most cases of human monkeypox were associated with direct animal contact, other routes of transmission cannot be excluded.