IMMUNOSUPPRESSIVE ACTION OF QINGHAOSU
IMMUNOSUPPRESSIVE ACTION OF QINGHAOSU作者机构：Shanghai Institute of Immunology Laboratory of Immunobiochemistry
出 版 物：《Science China Chemistry》 (中国科学:化学(英文版))
年 卷 期：1984年第27卷第4期
页 面：398-406页
核心收录：
主 题：QHS IMMUNOSUPPRESSIVE ACTION OF QINGHAOSU ACTION
摘 要：Qinghaosu （青蒿素）, isolated and purified from the Chinese herb Artemisia annua Linn（黄花蒿）, and identified as a sesquiterpene with a peroxide bridge and lactone structure,is a highly potent and non-toxic new antimalaria drug. This paper reports the immunosup-pressive action of its water soluble derivative （hemisuccinate Na, QHS）. The remarkable sup-pression by QHS of the in vitroHTdR incorporation by mitogen-stimulated mouse spleencells and human peripheral lymphocytes, as well as the spontaneous incorporation by mousethymocytes and blood cells from some leukemia patients is presented and its characteristics aredescribed. The in vivo effect as shown by quantitative PFC is studied and the differencebetween the present in vitro and in vivo effects is investigated. The possible mechanism ofinhibition and discrepancy in effects are discussed.
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