CD13/APN expression in peripheral blood lymphocytes and skin lesions in patients with advanced psoriasis vulgaris

作     者：Liu Taihua Liu Defang Chen Yihua Hu Zonghai Chen Lu Luo Chen Xu Zhejuan 

作者机构：Department of Dermatology Chengdu Military General Hospital Chengdu 610083 China Department of Traditional Chinese Medicine Chengdu Military General Hospital Chengdu-610083 China Department of Pathology Chengdu Military General Hospital Chengdu 610083 China Department of Clinical Laboratory Chengdu Military General Hospital Chengdu 610083 China 

出 版 物：《Journal of Medical Colleges of PLA(China)》 (中国人民解放军军医大学学报（英文版）)

年 卷 期：2009年第24卷第1期

页      面：25-30页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 100206[医学-皮肤病与性病学] 10[医学] 

主　　题：Psoriasis CD13/APN Peripheral blood Skin lesion 

摘      要：Objective： To observe the expression of CD13/APN in peripheral blood lymphocytes and skin lesions of patients with advanced psoriasis vulgaris, and discuss its effect on the pathogenesis of psoriasis. Methods： CD 13 expression in peripheral blood lymphocytes and skin lesions was detected by flow cytometry and imrnunohistochemical technique, respectively. Results were compared with those of healthy controls. Results： CD 13 expression was significantly higher in peripheral blood lymphocytes of patients with advanced psoriasis vulgaris than in that of healthy controls, and in skin lesions than in healthy skin tissues. The expression was mainly in the suprabasal layers of skin lesions, and positively correlated to PASI （R 0.78029）. Conclusion： The significantly higher expression of CD13 in peripheral blood lymphocytes and skin lesions of the patients with advanced psoriasis vulgaris probably is related to immunological abnormality, blood vessel abnormality and proliferation of keratinocyte in the pathogenic course of psoriasis. It may be a novel and effective way to treat psoriasis with specific CD13 inhibitors.