The application of Tau protein testing to gastric cancer patients treated with paclitaxel

作     者：WANG Qiong WANG NanYao SHAO GuoYi QIAN JianZhong YUAN Ming LI SuYi 

作者机构：Department of Oncology the Affiliated Jiangyin Hospital of Southeast University Medical College Department of Surgery the Affiliated Jiangyin Hospital of Southeast University Medical College Department of Pathology the Affiliated Jiangyin Hospital of Southeast University Medical College Department of Oncology the Affiliated Zhongda Hospital of Southeast University Medical College 

出 版 物：《Chinese Science Bulletin》 (中国科学通报)

年 卷 期：2013年第58卷第36期

页      面：4641-4646页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by City Health Administration Scientific Research Foundation of Wuxi(XM1006) 

主　　题：Tau蛋白 紫杉醇 胃癌 治疗 患者 蛋白表达 测试 应用 

摘      要：Paclitaxel is one of the main drugs used to treat gastric cancer,but many tumors develop drug resistance,resulting in treatment *** levels of expression of Tau protein in breast tumors have been found to be related to paclitaxel resistance,suggesting that Tau protein expression may predict breast cancer sensitivity to paclitaxel *** determine whether Tau protein expression can predict gastric cancer sensitivity to paclitaxel,we assayed Tau protein expression levels in gastric cancer specimens from 70 *** observed Tau protein expression in 54 of 70(77.1%)*** in gastric cancer cell lines showed that Tau protein expression was significantly lower in BGC823 than in MKN45 cells(P=0.0147).MTT assays showed that different concentrations of paclitaxel inhibited the growth of MKN45 and BGC823 cells,but inhibition and apoptosis were more obvious in cells expressing low levels of Tau *** chemotherapy was effective in 34 of the 70 patients(48.6%)and was significantly correlated with low expression of Tau protein(P0.01).These findings indicate that Tau protein is expressed in a high percentage of gastric cancers,with paclitaxel being more effective in tumors with low Tau expression.